Björn Titz, Ph.D.
BCR-ABL1 NETWORK
pYST heatmap
pY kinetics
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Systems Biology
Cancer Signaling
Interaction Networks
MassSpec Proteomics
Bjoern Titz, Ph.D.
Björn Titz, Ph.D.
Postdoctoral Scholar
Systems Biology of Cancer Signaling
Graeber Lab
University of California, Los Angeles

btitz (a) ucla (dot) edu










Education

2007 -
Postdoctoral Scholar, UCLA
2006
Ph.D., Karlsruhe Institute of Technology
2003
M.S. (Biochemistry), Kiel University

Research Interests

Apply systems biology approaches to gain insights into signaling networks of cancer cells; Combine large-scale measurements with computational analysis approaches; Integrate different large-scale data modalities for more comprehensive signaling models; Analyze biological networks at different scales from the whole network level to the individual binding epitope

Select Publications

bold = as first author or equally contributed first author

1.
Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, et al. Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling. Sci Signal. 2011;4(166):ra18.
2.
Titz B, Low T, Komisopoulou E, Chen SS, Rubbi L, Graeber TG. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Oncogene. 2010 Nov 4;29(44):5895-5910.
3.
Zimman A, Chen SS, Komisopoulou E, Titz B, Martínez-Pinna R, Kafi A, et al. Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis. J. Proteome Res. 2010 Jun 4;9(6):2812-2824.
4.
Fossum E, Friedel CC, Rajagopala SV, Titz B, Baiker A, Schmidt T, et al. Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathog. 2009 Sep;5(9):e1000570.
5.
Titz B, Rajagopala SV, Goll J, Häuser R, McKevitt MT, Palzkill T, et al. The binary protein interactome of Treponema pallidum--the syphilis spirochete. PLoS ONE. 2008;3(5):e2292.
6.
Titz B, Häuser R, Engelbrecher A, Uetz P. The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo. FEMS Microbiol. Lett. 2007 May;270(1):49-57.
7.
Rajagopala SV, Titz B, Goll J, Parrish JR, Wohlbold K, McKevitt MT, et al. The protein network of bacterial motility. Mol. Syst. Biol. 2007;3:128.
8.
Titz B, Rajagopala SV, Ester C, Häuser R, Uetz P. Novel conserved assembly factor of the bacterial flagellum. J. Bacteriol. 2006 Nov;188(21):7700-7706.
9.
Titz B, Thomas S, Rajagopala SV, Chiba T, Ito T, Uetz P. Transcriptional activators in yeast. Nucleic Acids Res. 2006;34(3):955-967.
10.
Titz B, Dietrich S, Sadowski T, Beck C, Petersen A, Sedlacek R. Activity of MMP-19 inhibits capillary-like formation due to processing of nidogen-1. Cell. Mol. Life Sci. 2004 Jul;61(14):1826-1833.
11.
Titz B, Schlesner M, Uetz P. What do we learn from high-throughput protein interaction data? Expert Rev Proteomics. 2004 Jun;1(1):111-121.