UCLA Metabolomics Center's contribution to scientific publications

2021

Metabolic plasticity drives development during mammalian embryogenesis.
Sharpley MS, Chi F, ten Hoeve J, Banerjee U.
Dev Cell. 2021 Aug 23;56(16):2329-2347.e6. PMID:34428399

Elevated asparagine biosynthesis drives brain tumor stem cell metabolic plasticity and resistance to oxidative stress.
Thomas TM, Miyaguchi K, Edwards LA, Wang H, Wollebo H, Aiguo L, Murali R, Wang Y, Braas D, Michael JS, Andres AM, Zhang M, Khalili K, Gottlieb RA, Perez JM, Yu JS.
Mol Cancer Res. 2021 Aug;19(8):1375-1388. PMID:33863814

Mitohormesis reprograms macrophage metabolism to enforce tolerance.
Timblin GA, Tharp KM, Ford B, Winchenster JM, Wang J, Zhu S, Khan RI, Louie Sk, Iavarone AT, ten Hoeve J, Nomura DK, and Stahl A.
Nat Metab. 2021 May 20;3(5):618-635

Adhesion-mediated mechanosignaling forces mitohormesis.
Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, ten Hoeve J, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM.
Cell Metab. 2021 May 17:S1550-4131(21)00183-2. PMID: 34019840.

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6 A/PFKP/LDHB axis.
Qing Y, Dong L, Gao L, Li C, Li Y, Han L, Prince E, Tan B, Deng X, Wetzel C, Shen C, Gao M, Chen Z, Li W, Zhang B, Braas D, ten Hoeve J, Sanchez GJ, Chen H, Chan LN, Chen CW, Ann D, Jiang L, Muschen M, Marcucci G, Plas DR, Li Z, Su R, and Chen J.
Mol Cell. 2021 Jan 6;S1097-2765(20)30947-3. PMID: 33434505

2020

Pressure-driven mitochondrial transfer pipeline generates mamalian cells of desired genetic combinations and fates.
Patananan AN, Sercel AJ, Wu T-H, Ahsan FM, Torres Jr A, Kennedy S, Vandiver A, Collier AJ, Mehrabi A, Lew JV, Zakin L, Rodriguez N, Sixto M, Tadros W, Lazar A, Sieling PA, Nguyen TL, Dawson ER, Braas D, Golovato J, Cisneros L, Vaske C, Plath K, Rabizadeh S, Niazi KR, Chiou P-Y, Teitell MA.
Cell Reports. 2020 Dec 29, 33(13), 108562.

Role of cyanobacterial phosphoketolase in energy regulation and glucose secretion under dark anaerobic and osmotic stress conditions.
Chuang D, Liao JC.
Metab Eng. 2020 Dec 13;S1096-7176(20)30188-9. PMID: 33326847

Metabolic reprogramming and epigenetic changes of vital organs in SARS-Cov-2 induced systemic toxicity.
Li S, Ma F, Yokota T, Garcia Jr. G, Palermo A, Wang Y, Farrell C, Wang YC, Wu R, Zhou Z, Pan C, Morselli M, Teitell MA, Ryazantsev S, FishBein GA, ten Hoeve J, Arboleda VA, Bloom J, Dillon BJ, Pellegrini M, Lusis AJ, Graeber TG, Arumugaswami V, and Deb A.
JCI Insight. 2020 Dec 7;145027. PMID: 33284134

Glioblastoma utilizes fatty acids and ketone bodies for growth allowing progression during ketogenic diet therapy.
Sperry J, Gondro MC, Guo L, Brass D, Vanderveer-Harris N, Kim K, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI.
iScience. 2020 Aug;23(9):101453. PMID: 32861192

Metabolic flux analysis and fluxomics-driven determination of reaction free energy using multiple isotopes.
Xu J, Martien J, Gilbertson C, Ma Junyu, Amador-Noguez D, Park JO
Curr Opin Biotechnol. 2020 Aug;64:151-160. PMID: 32304936

Defining the ATPome reveals cross-optimization of metabolic pathways.
Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K
Nat Commun. 2020 Aug 28;11(1):4319. PMID: 32859923

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia.
Gang EJ, Kim HN, Hsieh YT, Ruan Y, Ogana HA, Lee S, Pham J, Geng H, Park E, Klemm L, Willman CL, Carroll WL, Mittelman SD, Orgel E, Oberley MJ, Parekh C, Deepa Bhojwani H, Wayne AS, Arcangelis Ad, Georges-Labouesse E, Wayner E, Bonig H, Minasyan A, ten Hoeve J, Graeber TG, Muschen M, Heisterkamp N, Kim YM
Blood 2020 Jul 9;136(2):210-223. PMID: 32219444

Glycolysis-independent glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis.
Chi F, Sharpley MS, Nagaraj R, Sen Roy S, Banerjee U.
Dev Cell. 2020 Apr 6;53(1):9-26.e4. PMID: 32197068

2019

Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis.
Palaskas NJ, Garcia JD, Shirazi R, Shin DS, Puig-Saus C, Braas D, Ribas A, Graeber TG
Cell Discov. 2019 Nov 26;5:62. PMID: 31798961

Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy.
Dhandapani PK, Begines-Moreno IM, Brea-Calvo G, Gärtner U, Graeber TG, Javier Sanchez G, Morty RE, Schönig K, ten Hoeve J, Wietelmann A, Braun T, Jacobs HT, Szibor M
Sci Rep. 2019 Sep 4;9(1):12741. PMID: 31484989

Mitochondrial metabolism and glutamine are essential for mesoderm differentiation of human pluripotent stem cells.
Lu V, Dahan P, Ahsan FM, Patananan AN, Roy IJ, Torres A, Nguyen RMT, Huang D, Braas D, Teitell MA
Cell Res. 2019 Jul;29(7):596-598. PMID: 31189991

Ampk regulates IgD expression but not energy stress with B cell activation.
Waters LR, Ahsan FM, Ten Hoeve J, Hong JS, Kim DNH, Minasyan A, Braas D, Graeber TG, Zangle TA, Teitell MA
Sci Rep. 2019 Jun 3;9(1):8176.

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.
Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW, Andrews E, Ajami NJ, Bonham KS, Brislawn CJ, Casero D, Courtney H, Gonzalez A, Graeber TG, Hall AB, Lake K, Landers CJ, Mallick H, Plichta DR, Prasad M, Rahnavard G, Sauk J, Shungin D, Vázquez-Baeza Y, White RA, Braun J, Denson LA, Jansson JK, Knight R, Kugathasan S, McGovern DPB, Petrosino JF, Stappenbeck TS, Winter HS, Clish CB, Franzosa EA, Vlamakis H, Xavier RJ, Huttenhower C
Nature. 2019 May;569(7758):655.

An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+Multiple Myeloma.
Xu S, Zhou T, Doh HM, Trinh KR, Catapang A, Lee JT, Braas D, Bayley NA, Yamada RE, Vasuthasawat A, Sasine JP, Timmerman JM, Larson SM, Kim Y, MacLeod AR, Morrison SL, Herschman HR
Cancer Res. 2019 May 15;79(10):2748-2760. doi: 10.1158/0008-5472.CAN-18-2799.

Novel Metabolomic Comparison of Arterial and Jugular Venous Blood in Severe Adult Traumatic Brain Injury Patients and the Impact of Pentobarbital Infusion.
Wolahan SM, Lebby E, Mao HC, McArthur D, Real C, Vespa P, Braas D, Glenn TC
J Neurotrauma. 2019 Jan 15;36(2):212–221. PMCID: PMC6338571.

Increased Lactate Dehydrogenase Activity is Dispensable in Squamous Carcinoma Cells of Origin.
Flores A ,Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Jolly J, Graham N, Christofk HR, Lowry WE
Nat Commun. 2019 Jan 9;10(1):91. doi: 10.1038/s41467-018-07857-9.

2018

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis.
Divakaruni AS, Hsieh WY, Minarrieta L, Duong TN, Kim KKO, Desousa BR, Andreyev AY, Bowman CE, Caradonna K, Dranka BP, Ferrick DA, Liesa M, Stiles L, Rogers GW, Braas D, Ciaraldi TP, Wolfgang MJ, Sparwasser T, Berod L, Bensinger SJ, Murphy AN
Cell Metab. 2018 Sep 4;28(3):490-503.e7. doi: 10.1016/j.cmet.2018.06.001. Epub 2018 Jun 28.

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.
Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR
Cell 175, no. 1 (September 20, 2018): 117-132.e21.https://doi.org/10.1016/j.cell.2018.08.017

Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling.
Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA
iScience. 2018 Jul 27;5:99–109

Hexokinase 2 Is Targetable for HK1 Negative, HK2 Positive Tumors from a Wide Variety of Tissues of Origin.
Xu S, Catapang A, Doh HM, Bayley NA, Lee JT, Braas D, Graeber TG, Herschman HR
J Nucl Med. 2018 Jun 7; PMID: 29880505

A Precision Therapeutic Strategy for Hexokinase 1-null, Hexokinase 2-positive Cancers.
Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR
Cancer Metab. 2018 Jun 28;6:7. doi: 10.1186/s40170-018-0181-8. eCollection 2018.

The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.
Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB
Cancer Cell. 2018 May 14;33(5):905-921.e5. doi: 10.1016/j.ccell.2018.04.002.

Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.
Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI.
Cancer Metab. 2018 Apr 17;6:4. doi: 10.1186/s40170-018-0177-4. eCollection 2018.

Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress.
Tsoi J, L Robert, K Paraiso, C Galvan, K Sheu, J Lay, DJL Wong, M Atefi, R Shirazi, X Wang, D Braas, CS Grasso, N Palaskas, A Ribas, TG Graeber.
Cancer Cell. S1535-6108(18)30122-3. doi: 10.1016/j.ccell.2018.03.017. Epub 2018 Apr 12.

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M.
Cell. 2018 Apr 5;173(2):470-484.e18. doi: 10.1016/j.cell.2018.02.048. Epub 2018 Mar 15.

B1a B cells require autophagy for metabolic homeostasis and self-renewal.
Clarke AJ, Riffelmacher T, Braas D, Cornall RJ, Simon A.
J Exp Med. 2018 Feb 5;215(2):399-413. doi: 10.1084/jem.20170771. Epub 2018 Jan 11.

2017

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.
Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A
Elife. 2017 Dec 12;6. pii: e29330. doi: 10.7554/eLife.29330. PMID: 29231167

Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line.
Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S.
Cell Cycle. 2017 Aug 18:0. doi: 10.1080/15384101.2017.1361069. PMID: 28820316

Lactate dehydrogenase activity drives hair follicle stem cell activation.
Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE
Nat Cell Biol. 2017 Aug 14. doi: 10.1038/ncb3575. PMID: 28812580

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.
Le TM, Poddar S, Capri JR, Abt ER, Kim W, Wei L, Uong NT, Cheng CM, Braas D, Nikanjam M, Rix P, Merkurjev D, Zaretsky J, Kornblum HI, Ribas A, Herschman HR, Whitelegge J, Faull KF, Donahue TR, Czernin J, Radu CG.
Nat Commun. 2017 Aug 14;8(1):241. doi: 10.1038/s41467-017-00221-3. PMCID: PMC5556071

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS.
Mol Cell. 2017 Jun 22. pii: S1097-2765(17)30394-5. doi: 10.1016/j.molcel.2017.05.030. PMID: 28648777

FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.
Hirano A, Braas D, Fu YH, Ptáček LJ.
Cell Rep. 2017 Apr 11;19(2):255-266. doi: 10.1016/j.celrep.2017.03.041.

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.
Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, Müschen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG.
Mol Syst Biol. 2017 Feb 15;13(2):914. doi: 10.15252/msb.20167159 PMID: 28202506.

Metabolic gatekeeper function of B-lymphoid transcription factors.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M.
Nature 2017 Feb 13:1-5. doi: 10.1038/nature21076

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.
Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB.
Cell Rep. 2017 Jan 17;18(3):601-610. doi: 10.1016/j.celrep.2016.12.061. PMCID: PMC5260616

Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation.
Nagaraj R, Sharpley MS, Chi F, Braas D, Zhou Y, Kim R, Clark AT, Banerjee U.
Cell. 2017 Jan 12;168(1-2):210-223.e11. doi: 10.1016/j.cell.2016.12.026. Epub 2017 Jan 12. PMID: 28086092

2016

Role of Metabolomics in Traumatic Brain Injury Research.
Wolahan SM, Hirt D, Braas D, Glenn TC.
Neurosurg Clin N Am. 2016 Oct;27(4):465-72. doi: 10.1016/j.nec.2016.05.006. PMID: 27637396

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.
Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR.
Cell Stem Cell. 2016 Sep 3. pii: S1934-5909(16)30255-7. doi: 10.1016/j.stem.2016.08.008. PMID: 27618217

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells.
TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA.
Cell Metab. 2016 Jul 27. pii: S1550-4131(16)30313-8. doi: 10.1016/j.cmet.2016.07.002. PMID: 27476976

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL
Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. PMID: 27293185

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells.
Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D Koehler CM, Graeber TG, Chiou PY, Teitell MA
Cell Metab. 2016 May 10;23(5):921-9. doi: 10.1016/j.cmet.2016.04.007. PMID: 27166949

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.
Krall AS, Xu S, Graeber TG, Braas D, Christofk HR.
Nat Commun. 2016 Apr 29;7:11457. doi: 10.1038/ncomms11457. PMID: 27126896, PMCID: PMC4855534

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.
Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PA, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR.
Cell Rep. 2016 Feb 23;14(7):1590-601. doi: 10.1016/j.celrep.2016.01.057. Epub 2016 Feb 11. PMID: 26876179, PMCID: PMC4816454

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
Li W, Cohen A, Sun Y, Squires J, Braas D, Graeber TG, Du L, Li G, Li Z, Xu X, Chen X, Huang J.
Mol Cancer Res. 2016 Apr;14(4):344-53. doi: 10.1158/1541-7786.MCR-15-0466. Epub 2016 Feb 1. PMID: 26832214, PMCID: PMC4834240

2015

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J.
Cell Metab. 2015 Sep 1;22(3):508–515. PMID: 26190651

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.
Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR.
Nat Commun. 2015;6:8873. PMID: 26561297

2014

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J.
Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14.

Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.
Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR.
Cell Metab. 2014 Apr 1;19(4):694-701. doi: 10.1016/j.cmet.2014.03.009.